Prediction of apparent equilibrium solubility of indomethacin compounded with silica by 13C solid state NMR.

@article{Watanabe2002PredictionOA,
  title={Prediction of apparent equilibrium solubility of indomethacin compounded with silica by 13C solid state NMR.},
  author={Tomoyuki Watanabe and Susumu Hasegawa and Naoki Wakiyama and Akira Kusai and M. J. H. Senna},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={248 1-2},
  pages={123-9}
}
The apparent equilibrium solubility (AES) of indomethacin increased by co-grinding with silica. Change in the long- and short range disorder of indomethacin by co-grinding was examined by X-ray powder diffraction and 13C solid state NMR, respectively, to elucidate the increased AES. Since the increase in AES was particularly marked after complete disappearance of X-ray diffraction peaks, we attributed the enhanced AES primarily to the short range disorder on the molecular basis. This was… CONTINUE READING