Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex.

@article{Wu1999PredictionOA,
  title={Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex.},
  author={Joseph C Wu and Monte S. Buchsbaum and J. Christian Gillin and Cheuk Tang and S Cadwell and Michael Wiegand and Ahmand Najafi and Ehud Klein and Kevin C. Hazen and William E. Bunney and James H. Fallon and David B. Keator},
  journal={The American journal of psychiatry},
  year={1999},
  volume={156 8},
  pages={1149-58}
}
OBJECTIVE Sleep deprivation has been shown to have an antidepressant benefit in a subgroup of depressed patients. Functional imaging studies by the authors and others have suggested that patients with elevated metabolic rates in the anterior cingulate gyrus at baseline are more likely to respond to either sleep deprivation or antidepressant medications than patients with normal metabolic rates. The authors extend their earlier work in a larger group of patients and explore additional brain… CONTINUE READING

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