Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine.

@article{Cockcroft1987PredictionOA,
  title={Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine.},
  author={Donald W. Cockcroft and K Y Murdock and Julie Kirby and Frederick E. Hargreave},
  journal={The American review of respiratory disease},
  year={1987},
  volume={135 1},
  pages={264-7}
}
Previous data have indicated that airway responsiveness to allergen, expressed as the provocation concentration causing a 20% FEV1 fall (PC20), was dependent on nonallergic airway responsiveness (histamine PC20) and sensitivity to allergen (skin sensitivity or end-point titration). From retrospective data in 24 subjects, we developed a formula to predict allergen PC20 and examined its accuracy prospectively in 26 new subjects undergoing allergen inhalation test with doubling allergen… CONTINUE READING

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