Prediction of acetaminophen concentrations in overdose patients using a Bayesian pharmacokinetic model.

@article{Gentry1994PredictionOA,
  title={Prediction of acetaminophen concentrations in overdose patients using a Bayesian pharmacokinetic model.},
  author={Chris A. Gentry and Frank P Paloucek and Keith A. Rodvold},
  journal={Journal of toxicology. Clinical toxicology},
  year={1994},
  volume={32 1},
  pages={
          17-30
        }
}
A pharmacokinetic program using population-based parameter estimates and a Bayesian forecasting model was retrospectively evaluated for predicting acetaminophen serum concentrations in overdose patients. Dynamic disposition factors known to affect acetaminophen disposition (emesis, activated charcoal, N-acetylcysteine, etc.) were included in the program. Twenty six patients who reported an acetaminophen ingestion of at least 70 mg/kg within 24 h of presentation to the hospital and had at least… 
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