Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients.

Abstract

Instability of microsatellite repeat sequences has been observed in colorectal carcinomas and in extracolonic malignancies, predominantly endometrial tumours, occurring in the context of hereditary non-polyposis colorectal cancer (HNPCC). Microsatellite instability (MSI) as a feature of human DNA mismatch repair (MMR)-driven tumourigenesis of the uterine… (More)

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@article{Leeuw2000PredictionOA, title={Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients.}, author={Wiljo J F de Leeuw and Jan Willem F Dierssen and Hans F. A. Vasen and J T Wijnen and Gemma G Kenter and Hanne Meijers-Heijboer and A H J T Brocker-Vriends and Astrid Tenden Stormorken and Pal Moller and Fred H. Menko and C. J. Cornelisse and Hans Morreau}, journal={The Journal of pathology}, year={2000}, volume={192 3}, pages={328-35} }