Prediction of a common beta-propeller catalytic domain for fructosyltransferases of different origin and substrate specificity.

@article{Pons2000PredictionOA,
  title={Prediction of a common beta-propeller catalytic domain for fructosyltransferases of different origin and substrate specificity.},
  author={Tirso Pons and Lazaro E. Hernandez and F{\'a}tima Lucia Ramos Batista and Glay Chinea},
  journal={Protein science : a publication of the Protein Society},
  year={2000},
  volume={9 11},
  pages={2285-91}
}
The three-dimensional (3D) structure of fructan biosynthetic enzymes is still unknown. Here, we have explored folding similarities between reported microbial and plant enzymes that catalyze transfructosylation reactions. A sequence-structure compatibility search using TOPITS, SDP, 3D-PSSM, and SAM-T98 programs identified a beta-propeller fold with scores above the confidence threshold that indicate a structurally conserved catalytic domain in fructosyltransferases (FTFs) of diverse origin and… CONTINUE READING