Prediction of Tissue to Plasma Concentration Ratios of Drugs in the Rat from Experimentally Estimated Volume of Distribution: Application of Allometry.

@article{Mahmood2017PredictionOT,
  title={Prediction of Tissue to Plasma Concentration Ratios of Drugs in the Rat from Experimentally Estimated Volume of Distribution: Application of Allometry.},
  author={Iftekhar Mahmood},
  journal={Current drug metabolism},
  year={2017},
  volume={19 2},
  pages={
          155-164
        }
}
BACKGROUND In Physiologically Based Pharmacokinetic (PBPK) models, the most important input parameter is tissue-to-plasma partition coefficient (Kp). Over the years, several empirical methods have been developed to predict Kp in animals. OBJECTIVES The objective of this study was to propose two allometric methods to predict Kp from experimentally determined in vivo volume of distribution at steady state (Vss). METHOD In one method, Vss was allometrically predicted (using a fixed exponent 1… CONTINUE READING

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