Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients: Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms

@inproceedings{Lima2014PredictionOM,
  title={Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients: Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms},
  author={Aurea Lima and Joaquim Monteiro and Miguel Bernardes and Hugo Sousa and Rita I. Azevedo and V{\'i}tor Seabra and Rui Medeiros},
  booktitle={BioMed research international},
  year={2014}
}
OBJECTIVE Methotrexate (MTX), the most used drug in rheumatoid arthritis (RA) treatment, showing variability in clinical response, is often associated with genetic polymorphisms. This study aimed to elucidate the role of methylenetetrahydrofolate reductase (MTHFR) C677T and aminoimidazole carboxamide adenosine ribonucleotide transformylase (ATIC) T675C polymorphisms and clinicopathological variables in clinical response to MTX in Portuguese RA patients. METHODS Study included 233 RA patients… CONTINUE READING
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