Prediction of Maintenance Dose Required to Attain a Desired Drug Concentration at Steady-state From a Single Determination of Concentration After an Initial Dose

@article{Slattery1980PredictionOM,
  title={Prediction of Maintenance Dose Required to Attain a Desired Drug Concentration at Steady-state From a Single Determination of Concentration After an Initial Dose},
  author={John T. Slattery and Milo Gibaldi and Jeffrey R. Koup},
  journal={Clinical Pharmacokinetics},
  year={1980},
  volume={5},
  pages={377-385}
}
SummaryStrong correlations have been reported between drug concentrations at steady-state and a single drug concentration determined sometime after an initial dose for lithium, nortriptyline, Imipramine, desipramine, choramphenicol and theophylline. The mathematical basis of these relationships suggests that a one point method for predicting steady-state drug concentrations and individual dosing requirements should be widely applicable to most drugs and should be valid for patients having a… CONTINUE READING

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