Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging

  title={Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging},
  author={Heather C Whalley and Jessika E. Sussmann and Liana Romaniuk and Tiffany T Stewart and Martina Papmeyer and Emma Sprooten and Suzanna Hackett and Jeremy Hall and Stephen M Lawrie and Andrew M. McIntosh},
  booktitle={PloS one},
OBJECTIVE Bipolar disorder is a highly heritable condition. First-degree relatives of affected individuals have a more than a ten-fold increased risk of developing bipolar disorder (BD), and a three-fold risk of developing major depressive disorder (MDD) than the general population. It is unclear however whether differences in brain activation reported in BD and MDD are present before the onset of illness. METHODS We studied 98 young unaffected individuals at high familial risk of BD and 58… CONTINUE READING
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