Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

  title={Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores},
  author={Julie Lecarpentier and Valentina Silvestri and Karoline B Kuchenbaecker and Daniel Barrowdale and Joe Dennis and Lesley McGuffog and Penny Soucy and Goska Leslie and Piera Rizzolo and Anna Sara Navazio and Virginia Valentini and Veronica Zelli and A. S. C. Lee and Ali Amin Al Olama and Jonathan P. Tyrer and Melissa C. Southey and Esther M John and Thomas A. Conner and David E. Goldgar and Saundra M Buys and Ramūnas Janavi{\vc}ius and Linda Roslyn Steele and Yuan Chun Ding and Susan L. Neuhausen and Thomas v. O. Hansen and Ana Os{\'o}rio and Jeffrey N. Weitzel and Angela Toss and Veronica Medici and Laura Cortesi and Ines Zanna and Domenico Palli and Paolo Radice and Siranoush Manoukian and Bernard Peissel and Jacopo Azzollini and Alessandra Viel and Giulia Cini and Giuseppe Damante and Stefania Tommasi and Paolo Peterlongo and Florentia Fostira and Ute Hamann and D. Gareth Evans and Alex Henderson and Carole Brewer and Diana Eccles and Jackie Cook and Kai-ren Ong and Lisa Walker and Lucy E. Side and Mary E M Porteous and Rosemarie Davidson and Shirley Victoria Hodgson and Debra Frost and Julian Adlard and Louise Izatt and Ros Eeles and Steve Ellis and Marc Tischkowitz and Andrew K. Godwin and Alfons Meindl and Andrea Gehrig and Bernd Dworniczak and Christian Sutter and Christoph Engel and Dieter Niederacher and Doris Steinemann and Eric Hahnen and Jan Hauke and Kerstin Rhiem and Karin Kast and Norbert Arnold and Nina Ditsch and Shan Wang-gohrke and Barbara Wappenschmidt and Dorothea Wand and Christine Lasset and Dominique Stoppa-Lyonnet and Muriel Belotti and Francesca Damiola and Laure Barjhoux and Sylvie Mazoyer and Mattias Van Heetvelde and Bruce Poppe and Kim De Leeneer and Kathleen B.M. Claes and Miguel de la Hoya and Vanesa Garc{\'i}a-Barber{\'a}n and Trinidad Cald{\'e}s and Pedro Perez Segura and Johanna I. Kiiski and Kristiina Aittom{\"a}ki and Sofia Khan and Heli Nevanlinna and Christi J. van Asperen and Tibor Vaszk{\'o} and Mikl{\'o}s K{\'a}sler and Edith Ol{\'a}h and Judith Balma{\~n}a and Sara Guti{\'e}rrez-Enr{\'i}quez and Orland D{\'i}ez and {\'A}lex Teul{\'e} and Angel Izquierdo and Esther Darder and Joan Brunet and Jes{\'u}s Del Valle and Lidia Feliubadalo and Miquel Angel Pujana and Conxi L{\'a}zaro and Adalgeir Arason and Bjarni A. Agnarsson and Oskar Th. Johannsson and Rosa Bjork Barkardottir and Elisa Alducci and Silvia Tognazzo and Marco Montagna and Manuel R. Teixeira and Pedro S{\^e}co e Pinto and Amanda B. Spurdle and Helene Holland and Jong Won Lee and Min Hyuk Lee and Jihyoun Lee and Sung-Won Kim and Eunyoung Kang and Zisun Kim and Priyanka Sharma and Timothy R. Rebbeck and Joseph Vijai and Mark Gregory Robson and Anne Lincoln and Jacob Musinsky and Pragna Gaddam and Yen Yee Tan and Andreas Berger and Christian F. Singer and Jennifer T Loud and Mark H Greene and Anna Marie Mulligan and Gord Glendon and Irene L. Andrulis and Amanda Ewart Toland and Leigha Senter and Anders Bojesen and Henriette Roed Nielsen and Anne-Bine Skytte and Lone Sunde and Uffe Birk Jensen and Inge S{\o}kilde Pedersen and Lotte Krogh and Torben Kruse and Maria A Caligo and Sook-Yee Yoon and Soo-Hwang Teo and Anna von Wachenfeldt and Dezheng Huo and Sarah M. Nielsen and Olufunmilayo I. Olopade and Katherine L Nathanson and Susan M Domchek and Christa Lorenchick and Rachel C. Jankowitz and Ian James Campbell and Paul A. James and Gillian Mitchell and Nick Orr and Sue Kyung Park and Mads Thomassen and Kenneth Offit and Fergus J. Couch and Jacques Simard and Douglas F. Easton and Georgia Chenevix-Trench and Rita Schmutzler and Antonis C. Antoniou and Laura Ottini},
  booktitle={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigated-for the first time to our knowledge-associations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/ 2 mutations and implications for cancer risk prediction. Materials and Methods We genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of… CONTINUE READING


Publications citing this paper.

BRCA2 and Other DDR Genes in Prostate Cancer

  • Cancers
  • 2019


Publications referenced by this paper.