Prediction of Biologic Aggressiveness in Colorectal Cancer by p53/K-ras-2 Topographic Genotyping.

@article{Finkelstein1996PredictionOB,
  title={Prediction of Biologic Aggressiveness in Colorectal Cancer by p53/K-ras-2 Topographic Genotyping.},
  author={Finkelstein and Przygodzki and Pricolo and Sakallah and Swalsky and C Bakker and Lanning and Bland and D Cooper},
  journal={Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology},
  year={1996},
  volume={1 1},
  pages={5-28}
}
Background: Topographic genotyping is a system of solid tissue molecular analysis designed to correlate microscopic alterations with specific forms of gene damage. In this system, microscopic targets are selected on the basis of cellular and immunohistochemical features. Minute tissue samples corresponding to these targets are precisely removed and analyzed for the presence and specific type of oncogene/tumor suppressor gene damage by means of polymerase chain reaction (PCR) followed by DNA… CONTINUE READING

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Minute tissue samples corresponding to these targets are precisely removed and analyzed for the presence and specific type of oncogene / tumor suppressor gene damage by means of polymerase chain reaction ( PCR ) followed by DNA sequencing .
Minute tissue samples corresponding to these targets are precisely removed and analyzed for the presence and specific type of oncogene / tumor suppressor gene damage by means of polymerase chain reaction ( PCR ) followed by DNA sequencing .
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