Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses

@article{Giorgio2013PredictionOA,
  title={Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses},
  author={Juliana Perez Di Giorgio and Gabriela Soto and Karina Alleva and Cintia Jozefkowicz and Gabriela Amodeo and Jorge Prometeo Muschietti and Nicol{\'a}s Daniel Ayub},
  journal={The Journal of Membrane Biology},
  year={2013},
  volume={247},
  pages={107-125}
}
Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence… CONTINUE READING
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