Prediction of Antibacterial Activity from Physicochemical Properties of Antimicrobial Peptides

Abstract

Consensus is gathering that antimicrobial peptides that exert their antibacterial action at the membrane level must reach a local concentration threshold to become active. Studies of peptide interaction with model membranes do identify such disruptive thresholds but demonstrations of the possible correlation of these with the in vivo onset of activity have… (More)
DOI: 10.1371/journal.pone.0028549

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