Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors.

@article{Kerkhof2014PredictionMF,
  title={Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors.},
  author={Hanneke J. M. Kerkhof and Sita M. A. Bierma-Zeinstra and Nigel K Arden and Sarah Jane Metrustry and Martha C. Casta{\~n}o-Betancourt and D J Hart and Albert Hofman and Fernando Rivadeneira and E H G Oei and Tim D. Spector and Andr{\'e} G. Uitterlinden and Anne-Sophie Janssens and Ana M Valdes and Joyce B. J. van Meurs},
  journal={Annals of the rheumatic diseases},
  year={2014},
  volume={73 12},
  pages={2116-21}
}
OBJECTIVE To develop and validate a prognostic model for incident knee osteoarthritis (KOA) in a general population and determine the value of different risk factor groups to prediction. METHODS The prognostic model was developed in 2628 individuals from the Rotterdam Study-I (RS-I). Univariate and multivariate analyses were performed for questionnaire/easily obtainable variables, imaging variables, genetic and biochemical markers. The extended multivariate model was tested on discrimination… CONTINUE READING
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