Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.

Abstract

When an enoylreductase enzyme of a modular polyketide synthase reduces a propionate extender unit that has been newly added to the growing polyketide chain, the resulting methyl branch may have either S or R configuration. We have uncovered a correlation between the presence or absence of a unique tyrosine residue in the ER active site and the chirality of… (More)
DOI: 10.1016/j.chembiol.2008.09.012

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