Prediction and diagnosis of type 1 diabetes using beta-cell autoantibodies.

  title={Prediction and diagnosis of type 1 diabetes using beta-cell autoantibodies.},
  author={Manou R. Batstra and Henk Jan Aanstoot and Paul Herbrink},
  journal={Clinical laboratory},
  volume={47 9-10},
The clinical manifestation of type 1 diabetes is the endpoint of a long-lasting immune-mediated destruction process of the B-cells. Autoantibodies originating from this process can be applied in the diagnosis and clinical discrimination of autoimmune diabetes as well as in the prediction of this disease. At clinical diagnosis between 80-90% of patients with type 1 diabetes are positive for antibodies to B-cell antigens, such as ICA and antibodies to glutamic acid decarboxylase or IA2. These… CONTINUE READING
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