Prediction and characterization of cyclic proteins from sequences in three domains of life.

@article{Kedarisetti2014PredictionAC,
  title={Prediction and characterization of cyclic proteins from sequences in three domains of life.},
  author={Pradyumna Kedarisetti and Marcin J. Mizianty and Quentin Kaas and David J. Craik and Lukasz A. Kurgan},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1844 1 Pt B},
  pages={181-90}
}
Cyclic proteins (CPs) have circular chains with a continuous cycle of peptide bonds. Their unique structural traits result in greater stability and resistance to degradation when compared to their acyclic counterparts. They are also promising targets for pharmaceutical/therapeutic applications. To date, only a few hundred CPs are known, although recent studies suggest that their numbers might be substantially higher. Here we developed a first-of-its-kind, accurate and high-throughput method… CONTINUE READING
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