Predicting transmembrane beta-barrels in proteomes.

  title={Predicting transmembrane beta-barrels in proteomes.},
  author={Henry R. Bigelow and Donald Petrey and Jinfeng Liu and Dariusz Przybylski and Burkhard Rost},
  journal={Nucleic acids research},
  volume={32 8},
Very few methods address the problem of predicting beta-barrel membrane proteins directly from sequence. One reason is that only very few high-resolution structures for transmembrane beta-barrel (TMB) proteins have been determined thus far. Here we introduced the design, statistics and results of a novel profile-based hidden Markov model for the prediction and discrimination of TMBs. The method carefully attempts to avoid over-fitting the sparse experimental data. While our model training and… CONTINUE READING
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