Predicting toxicokinetic parameters in humans from toxicokinetic data acquired from three small mammalian species.

@article{Bachmann1989PredictingTP,
  title={Predicting toxicokinetic parameters in humans from toxicokinetic data acquired from three small mammalian species.},
  author={Kenneth A. Bachmann},
  journal={Journal of applied toxicology : JAT},
  year={1989},
  volume={9 5},
  pages={331-8}
}
Values for the independent kinetic variables, clearance (CL) and volume of distribution (V), for six xenobiotics--antipyrine, ethosuximide, phencyclidine, theophylline, valproic acid and warfarin--were culled from the literature for each of three small subhuman species and for humans, and then allometrically scaled. Scaling was performed in two ways. First, using kinetic data acquired for three small subhuman species and for man, scaled parameters were observed for goodness of fit to a standard… CONTINUE READING

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