Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1.

@article{Mentink2013PredictingTT,
  title={Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1.},
  author={Anouk Mentink and Marc Hulsman and Nathalie Groen and Ruud Licht and Koen J. Dechering and Johan van der Stok and Hugo Alves and Wouter J. A. Dhert and Eugene P. van Someren and Marcel J. T. Reinders and Clemens A van Blitterswijk and Jan-Paul de Boer},
  journal={Biomaterials},
  year={2013},
  volume={34 19},
  pages={4592-601}
}
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated hMSCs from 62 donors and characterized systematically their in vitro lineage differentiation capacity, gene expression signature and in vivo capacity for ectopic bone formation… CONTINUE READING
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