Predicting the risk of developmental toxicity from in vitro assays.

  title={Predicting the risk of developmental toxicity from in vitro assays.},
  author={H. Spielmann},
  journal={Toxicology and applied pharmacology},
  volume={207 2 Suppl},
  • H. Spielmann
  • Published 2005 in Toxicology and applied pharmacology
Reproductive toxicity refers to the adverse effects of a substance on any aspect of the reproductive cycle, including the impairment of reproductive function, the induction of adverse effects in the embryo, such as growth retardation, malformations, and death. Due to the complexity of the mammalian reproductive cycle, it is impossible to model the whole cycle in a single in vitro system in order to detect chemical effects on mammalian reproduction. However, the cycle can be broken down in its… CONTINUE READING