Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Abstract

Immunotherapy using checkpoint-blocking antibodies against targets such as CTLA-4 and PD-1 can cure melanoma and non-small cell lung cancer in a subset of patients. The presence of CD8 T cells in the tumor correlates with improved survival. We show that immuno-positron emission tomography (immuno-PET) can visualize tumors by detecting infiltrating… (More)
DOI: 10.1084/jem.20161950

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Cite this paper

@article{Rashidian2017PredictingTR, title={Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.}, author={Mohammad Rashidian and Jessica R Ingram and Michael Dougan and Anushka Dongre and Katherine A Whang and Camille LeGall and Juan Jose Cragnolini and Brian Bierie and Monica Gostissa and James Gorman and Gijsbert M. Grotenbreg and Atul K. Bhan and Robert A. Weinberg and Hidde L. Ploegh}, journal={The Journal of experimental medicine}, year={2017}, volume={214 8}, pages={2243-2255} }