Predicting the prognosis of undifferentiated pleomorphic soft tissue sarcoma: a 20‐year experience of 266 cases

@article{Vodanovich2019PredictingTP,
  title={Predicting the prognosis of undifferentiated pleomorphic soft tissue sarcoma: a 20‐year experience of 266 cases},
  author={Domagoj A Vodanovich and Tim Spelman and Deborah May and John L. Slavin and Peter F. M. Choong},
  journal={ANZ Journal of Surgery},
  year={2019},
  volume={89}
}
Undifferentiated pleomorphic sarcoma (UPS) is a rare malignant tumour of mesenchymal origin, which was conceived following re‐classification of malignant fibrous histiocytoma (MFH). The objective of this study is to determine prognostic factors for the outcome of UPS, following multi‐modal treatment. 
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16 Citations
Background Citations
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Methods Citations
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16 Citations

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Citation Type

Inflammatory undifferentiated pleomorphic sarcoma of the kidney with obstinate cough and fever as the first symptom: a case report and literature review
TLDR
A 60-year-old woman diagnosed withUndifferentiated pleomorphic sarcoma is a highly aggressive cancer that most commonly occurs in the extremities and trunk but is extremely rare in the kidney.
Pleomorphic Sarcoma in a Patient with Osteopetrosis.
TLDR
The case of a 53-year-old woman with previously undiagnosed osteopetrosis who presented with a pathologic proximal humeral fracture secondary to pleomorphic sarcoma, which was previously undescribed in the English literature is reported.
Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly.
  • Roos F. Bleckman, I. Acem, O. Zaikova
  • Medicine
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2021
Role of adjuvant chemotherapy in patients with localized, undifferentiated pleomorphic sarcoma of soft tissue: a population-based cohort study
TLDR
In patients with localized UPS, adjuvant chemotherapy tended to improve OS when tumors were ≥ 5 cm, especially when they were 10 to < 15 cm, and after PSM, adjUvant chemotherapy was significantly associated with improved OS.
The Impact of Surgical Margins and Adjuvant Radiotherapy in Patients with Undifferentiated Pleomorphic Sarcomas of the Extremities: A Single-Institutional Analysis of 192 Patients
TLDR
Negative margins and adjuvant radiotherapy were found to be independent prognostic factors in multivariate analysis and could underscore the beneficial prognostic impact of negative margins on LRFS and OS.
Undifferentiated Pleomorphic Sarcoma with Neoplastic Fever: A Retrospective Study
TLDR
This study retrospectively analyzed the clinical data of patients with UPS to provide a reference for the diagnosis and treatment of UPS with neoplastic fever, which is characterized by intratumoral necrosis and extensive edema of the surrounding soft tissues.
Establishment and characterization of NCC-UPS3-C1: a novel patient-derived cell line of undifferentiated pleomorphic sarcoma
TLDR
A novel UPS cell line is established using a surgically resected tumor from a patient with radiation-associated UPS and it is identified that the histone deacetylase inhibitor, romidepsin, is highly effective on NCC-UPS3-C1 cells.
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome.
TLDR
NCC-UPS4-C1, which is the first sarcoma cell line established from a patient with LFS, enables researchers to conduct vigorous preclinical research on UPS, and a potential drug for the treatment of UPS was suggested using well-characterized UPS cell lines.
Margin Assessment in Soft Tissue Sarcomas: Review of the Literature
TLDR
There is a great need for evidence-based standardization concerning the width of resection margins, and the need for a uniform description of the margin status for patients with STS is highlighted.
Serum lactate dehydrogenase as a novel prognostic factor for patients with primary undifferentiated pleomorphic sarcomas
TLDR
Preoperative serum LDH is an independent factor for OS in UPS patients, and it correlates with future surgical margin, and Kaplan–Meier curves showed that patients with relatively high-serum LDH had poorer OS compared with those with low-seru LDH.
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