Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling.

@article{Sahneh2015PredictingTI,
  title={Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling.},
  author={Faryad Darabi Sahneh and Caterina M. Scoglio and Nancy A Monteiro-Riviere and Jim E Riviere},
  journal={Nanomedicine},
  year={2015},
  volume={10 1},
  pages={25-33}
}
AIM To assess the impact of biocorona kinetics on expected tissue distribution of nanoparticles (NPs) across species. MATERIALS & METHODS The potential fate of NPs in vivo is described through a simple and descriptive pharmacokinetic model using rate processes dependent upon basal metabolic rate coupled to dynamics of protein corona. RESULTS Mismatch of time scales between interspecies allometric scaling and the kinetics of corona formation is potentially a fundamental issue with… CONTINUE READING