Predicting the impact of a nonsterilizing vaccine against human immunodeficiency virus.

@article{Davenport2004PredictingTI,
  title={Predicting the impact of a nonsterilizing vaccine against human immunodeficiency virus.},
  author={Miles P. Davenport and Ruy M. Ribeiro and Dennis Chao and Alan S. Perelson},
  journal={Journal of virology},
  year={2004},
  volume={78 20},
  pages={11340-51}
}
Studies of human immunodeficiency virus (HIV) vaccines in animal models suggest that it is difficult to induce complete protection from infection (sterilizing immunity) but that it is possible to reduce the viral load and to slow or prevent disease progression following infection. We have developed an age-structured epidemiological model of the effects of a disease-modifying HIV vaccine that incorporates the intrahost dynamics of infection, a transmission rate and host mortality that depend on… CONTINUE READING
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