Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.

@article{Vardakou2011PredictingTH,
  title={Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.},
  author={Maria Vardakou and Annalisa Mercuri Mercuri and Tony Naylor and Daniele Rizzo and James M. Butler and Paul C. Connolly and Martin Sean John Wickham and Richard Martin Faulks},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={419 1-2},
  pages={192-9}
}
The disintegration of a capsule shell may determine the onset of drug dissolution from capsule formulations. In this study, the release of a rapidly dissolving model drug (paracetamol), from two hydroxypropyl methylcellulose capsules containing either carageenan (HPMC-C) or gellan gum (HPMC-G) and one hard gelatin (HG) capsule, were investigated using a conventional in vitro model, the USP dissolution apparatus I, and a novel in vitro model of the human gastric compartment, the dynamic gastric… CONTINUE READING