Predicting the effect of transfusing only phenotype-matched RBCs to patients with sickle cell disease: theoretical and practical implications.

@article{Castro2002PredictingTE,
  title={Predicting the effect of transfusing only phenotype-matched RBCs to patients with sickle cell disease: theoretical and practical implications.},
  author={Oswaldo L. Castro and S Gerald Sandler and Patricia E Houston-Yu and Sohail R. Rana},
  journal={Transfusion},
  year={2002},
  volume={42 6},
  pages={684-90}
}
BACKGROUND Transfusing only phenotype-matched RBCs has been recommended to reduce the incidence of alloimmunization to blood group antigens in patients with sickle cell disease (SCD). STUDY DESIGN AND METHODS The expected benefit of phenotype matching was determined by identifying which of the existing blood group alloantibodies in patients with SCD who received conventional transfusions would not have been formed if they had received only phenotype-matched RBCs. By use of each patient's… CONTINUE READING

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