Predicting the effect of steroids on membrane biophysical properties based on the molecular structure.

@article{Wenz2012PredictingTE,
  title={Predicting the effect of steroids on membrane biophysical properties based on the molecular structure.},
  author={Jorge J. Wenz},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1818 3},
  pages={896-906}
}
The relationship between sterol structure and the resulting effects on membrane physical properties is still unclear, owing to the conflicting results found in the current literature. This study presents a multivariate analysis describing the physical properties of 83 steroid membranes. This first structure-activity analysis supports the generally accepted physical effects of sterols in lipid bilayers. The sterol chemical substituents and the sterol/phospholipid membrane physical properties… CONTINUE READING