Predicting the druggability of protein-protein interactions based on sequence and structure features of active pockets.

@article{Dai2015PredictingTD,
  title={Predicting the druggability of protein-protein interactions based on sequence and structure features of active pockets.},
  author={Xinyu Dai and Run Yu Jing and Yanzhi Guo and Yong Dong and Yue Long Wang and Yuan Liu and Xuemei Pu and Menglong Li},
  journal={Current pharmaceutical design},
  year={2015},
  volume={21 21},
  pages={
          3051-61
        }
}
Protein-protein interactions (PPIs) are becoming highly attractive targets for drug discovery. Motivated by the rapid accumulation of PPI data in public database and the success stories concerning the targeting of PPIs, a machine-learning method based on sequence and structure properties was developed to access the druggability of PPIs. Here, a… CONTINUE READING