Predicting the conformation of proteins. Man versus machine.


Two types of approaches for predicting the conformation of proteins from sequence data have lately received attention: 'black box' tools that generate fully automated predictions of secondary structure from a set of homologous protein sequences, and methods involving the expertise of a human biochemist who is assisted, but not replaced, by computer tools. A friendly controversy has emerged as to which approach offers a brighter future. In fact, both are necessary. Nevertheless, a snapshot of the controversy at this instant offers much insight into the structure prediction problem itself.

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@article{Benner1993PredictingTC, title={Predicting the conformation of proteins. Man versus machine.}, author={Steven A. Benner and Dietlind L. Gerloff}, journal={FEBS letters}, year={1993}, volume={325 1-2}, pages={29-33} }