Predicting the Origins of Anti-Blood Group Antibody Specificity: A Case Study of the ABO A- and B-Antigens

@inproceedings{Makeneni2014PredictingTO,
  title={Predicting the Origins of Anti-Blood Group Antibody Specificity: A Case Study of the ABO A- and B-Antigens},
  author={Spandana Makeneni and Ye Ji and David C. Watson and Nathan M Young and Robert J. Woods},
  booktitle={Front. Immunol.},
  year={2014}
}
The ABO blood group system is the most important blood type system in human transfusion medicine. Here, we explore the specificity of antibody recognition toward ABO blood group antigens using computational modeling and biolayer interferometry. Automated docking and molecular dynamics simulations were used to explore the origin of the specificity of an anti-blood group A antibody variable fragment (Fv AC1001). The analysis predicts a number of Fv-antigen interactions that contribute to affinity… CONTINUE READING
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