Predicting stem cell fate changes by differential cell cycle progression patterns.

  title={Predicting stem cell fate changes by differential cell cycle progression patterns.},
  author={Marta Roccio and Daniel Schmitter and Marlen Knobloch and Yuya Okawa and Daniel Sage and Matthias P Lutolf},
  volume={140 2},
Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not been possible to probe this relationship systematically in live stem cells in vitro or in vivo. Alterations in stem cell cycle kinetics probably occur long before changes in phenotypic markers are apparent and could be used as predictive parameters to reveal changes in stem cell fate. To… CONTINUE READING
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