Predicting skull lesions after clinical transcranial MRI-guided focused ultrasound with acoustic and thermal simulations
@article{McDannold2019PredictingSL, title={Predicting skull lesions after clinical transcranial MRI-guided focused ultrasound with acoustic and thermal simulations}, author={Nathan J. McDannold and Phillip Jason White and Rees G. Cosgrove}, journal={arXiv: Medical Physics}, year={2019} }
Transcranial MRI-guided focused ultrasound (TcMRgFUS) thermal ablation is a noninvasive functional neurosurgery technique. Previous reports have shown that bone marrow damage in the skull can occur at high acoustic energies. While this damage is asymptomatic, it would be desirable to avoid it. Here we examined whether acoustic and thermal simulations can predict where the thermal lesions in the skull might occur. Post-treatment imaging was obtained at 3-15 months after 40 clinical TcMRgFUS…
One Citation
Computationally Efficient Transcranial Ultrasonic Focusing: Taking Advantage of the High Correlation Length of the Human Skull
- PhysicsIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
- 2020
The phase correction necessary for transcranial ultrasound therapy requires numerical simulation to noninvasively assess the phase shift induced by the skull bone and it is proposed here to perform the numerical simulation at 450 kHz and use the corresponding phases experimentally at 900 kHz.
References
SHOWING 1-10 OF 20 REFERENCES
Elementwise approach for simulating transcranial MRI-guided focused ultrasound thermal ablation
- PhysicsPhysical review research
- 2019
An elementwise approach to model transcranial MRI-guided focused ultrasound (TcMRgFUS) thermal ablation and shows how this approach can be used to optimize the relationship between CT-derived skull density and acoustic properties.
Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery
- MedicineIEEE Transactions on Biomedical Engineering
- 2004
The results demonstrate that standing waves may be formed within the skull during transcranial sonication leading to nonuniform skull heating, however, the results show that these effects can be sufficiently controlled to allow therapeutic ultrasound to be focused in the cranial base region of the brain without causing thermal damage to the scalp, skull or outer surface of thebrain.
Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures.
- MedicineJournal of neurosurgery
- 2018
There was no correlation between the mean skull density ratio (SDR) and the presence or absence of skull lesions, but the maximum energy applied with the Exablate system was significantly greater in patients with skull lesions than in those without.
Prediction of the skull overheating during high intensity focused ultrasound transcranial brain therapy
- Physics, MedicineIEEE Ultrasonics Symposium, 2004
- 2004
A model for computing the temperature elevation in the skull during high intensity focused ultrasound (HIFU) transcranial therapy using the density of the skull bone that can be obtained with high-resolution CT scans and 3D finite difference wave propagation software is proposed.
High‐intensity focused ultrasound for noninvasive functional neurosurgery
- MedicineAnnals of neurology
- 2009
This is the first report on successful clinical application of tcMRgHIFU in functional brain disorders, portraying it as safe and reliable for noninvasive neurosurgical interventions.
Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans.
- MedicineThe Journal of the Acoustical Society of America
- 2003
The acoustic properties of the skull can be deduced from high resolution CT scans and used to achieve a noninvasive adaptive focusing, which could have promising applications in brain tumor hyperthermia but also in transcranial ultrasonic imaging.
A non-invasive method for focusing ultrasound through the human skull.
- MedicinePhysics in medicine and biology
- 2002
The results demonstrate the feasibility of using the method for completely non-invasive ultrasound brain surgery and therapy and the phase correction algorithm successfully restored the focus inside the skull at a location within 1 mm from the intended focal point.
The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson's disease: a Phase I clinical trial.
- Medicine, PsychologyJournal of neurosurgery
- 2018
In the present study, which marks the first Phase I pilot study of unilateral MRgFUS pallidotomy for parkinsonian dyskinesia, the authors demonstrated the efficacy of pallidal lesioning using MRgfUS and certain limitations that are unavoidably associated with incomplete thermal lesions due to technical issues.
Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study
- Medicine, PsychologyMolecular Psychiatry
- 2014
This study demonstrates that bilateral thermal capsulotomy with MRgFUS can be used without inducing side effects to treat patients with medically refractory OCD, and if larger trials validate the safety, effectiveness and long-term durability of this new approach, this procedure could considerably change the clinical management of treatment-refractors.
Inducing therapeutic hypothermia via selective brain cooling: a finite element modeling analysis
- EngineeringMedical & Biological Engineering & Computing
- 2019
3D geometry of the head and carotid artery model based on the computed tomography (CT) were derived separately and the corresponding investigations were conducted to validate the reliability of the model.