Predicting rodent carcinogenicity of halogenated hydrocarbons by in vivo biochemical parameters.

@article{Kitchin1993PredictingRC,
  title={Predicting rodent carcinogenicity of halogenated hydrocarbons by in vivo biochemical parameters.},
  author={K. Kitchin and J. Brown and A. Kulkarni},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={1993},
  volume={13 4},
  pages={
          167-84
        }
}
Forty halogenated hydrocarbons of known rodent carcinogenicity (24 carcinogens, 16 noncarcinogens), including many promoters of carcinogenesis, nongenotoxic carcinogens, and hepatocarcinogens, were selected for study. The chemicals were administered by gavage in two dose levels to female Sprague-Dawley rats. The effects of these 40 chemicals on four biochemical assays [hepatic DNA damage by alkaline elution (DD), hepatic ornithine decarboxylase activity (ODC), serum alanine aminotransferase… Expand
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