Predicting riboswitch regulation on a genomic scale.

  title={Predicting riboswitch regulation on a genomic scale.},
  author={Jeffrey E Barrick},
  journal={Methods in molecular biology},
Riboswitches are vital components of many genomes. Covariance model searches for the characteristic architectures of riboswitch aptamer domains can be used to predict new examples of these structured RNAs. Since riboswitches generally function as cis-regulatory elements, examining the genomic contexts of these hits is critical for evaluating their biological relevance. With these two sources of comparative support, it is possible to identify riboswitches accurately from sequence information… CONTINUE READING