Predicting proteolytic sites in extracellular proteins: only halfway there

@article{Kliger2008PredictingPS,
  title={Predicting proteolytic sites in extracellular proteins: only halfway there},
  author={Yossef Kliger and Eyal Gofer and Assaf Wool and Amir Toporik and Avihay Apatoff and Moshe Olshansky},
  journal={Bioinformatics},
  year={2008},
  volume={24 8},
  pages={
          1049-55
        }
}
MOTIVATION Many secretory proteins are synthesized as inactive precursors that must undergo post-translational proteolysis in order to mature and become active. In the current study, we address the challenge of sequence-based discovery of proteolytic sites in secreted proteins using machine learning. RESULTS The results revealed that only half of the extracellular proteolytic sites are currently annotated, leaving over 3600 unannotated ones. Furthermore, we have found that only 6% of the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

E Bergeron
  • Biochem. Biophys. Res. Commun.,
  • 2005

Inhibitors of proprotein convertases

J. D. Bendtsen
  • J . Mol . Med .
  • 2005

Improved prediction of signal peptides: SignalP 3.0

Bendtsen, J.D
  • J. Mol. Biol.,
  • 2004

Prediction of proprotein convertase cleavage sites

P Duckert
  • Protein Eng. Des. Sel.,
  • 2004

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