Predicting protein stability changes from sequences using support vector machines

@article{Capriotti2005PredictingPS,
  title={Predicting protein stability changes from sequences using support vector machines},
  author={Emidio Capriotti and Piero Fariselli and Remo Calabrese and Rita Casadio},
  journal={Bioinformatics},
  year={2005},
  volume={21 Suppl 2},
  pages={ii54-8}
}
MOTIVATION The prediction of protein stability change upon mutations is key to understanding protein folding and misfolding. At present, methods are available to predict stability changes only when the atomic structure of the protein is available. Methods addressing the same task starting from the protein sequence are, however, necessary in order to complete genome annotation, especially in relation to single nucleotide polymorphisms (SNPs) and related diseases. RESULTS We develop a method… CONTINUE READING

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