Predicting protein-protein interactions using graph invariants and a neural network

  title={Predicting protein-protein interactions using graph invariants and a neural network},
  author={Debra J. Knisley and Jeff Knisley},
  journal={Computational biology and chemistry},
  volume={35 2},
The PDZ domain of proteins mediates a protein-protein interaction by recognizing the hydrophobic C-terminal tail of the target protein. One of the challenges put forth by the DREAM (Discussions on Reverse Engineering Assessment and Methods) 2009 Challenge consists of predicting a position weight matrix (PWM) that describes the specificity profile of five PDZ domains to their target peptides. We consider the primary structures of each of the five PDZ domains as a numerical sequence derived from… CONTINUE READING


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