Predicting protein druggability.

  title={Predicting protein druggability.},
  author={Philip J. Hajduk and Jeffrey R. Huth and Christin Tse},
  journal={Drug discovery today},
  volume={10 23-24},
The ability to predict whether a particular protein can bind with high affinity and specificity to small, drug-like compounds based solely on its 3D structure has been a longstanding goal of structural biologists and computational scientists. The promise is that an accurate prediction of protein druggability can capitalize on the huge investments already made in structural genomics initiatives by identifying highly druggable proteins and using this information in target identification and… CONTINUE READING