Predicting population coverage of T-cell epitope-based diagnostics and vaccines

  title={Predicting population coverage of T-cell epitope-based diagnostics and vaccines},
  author={Huynh-Hoa Bui and John Sidney and Kenny Dinh and Scott Southwood and Mark J. Newman and Alessandro Sette},
  journal={BMC Bioinformatics},
  pages={153 - 153}
T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will elicit a response only in individuals that express an MHC molecule capable of binding that particular epitope. MHC molecules are extremely polymorphic and over a thousand different human MHC (HLA) alleles are known. A disproportionate amount of MHC polymorphism occurs in positions constituting the peptide-binding region, and as a result… CONTINUE READING
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