Predicting phenotypic variation in yeast from individual genome sequences

@article{Jelier2011PredictingPV,
  title={Predicting phenotypic variation in yeast from individual genome sequences},
  author={Rob Jelier and Jennifer I. Semple and Rosa Garcia-Verdugo and Ben Lehner},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={1270-1274}
}
A central challenge in genetics is to predict phenotypic variation from individual genome sequences. Here we construct and evaluate phenotypic predictions for 19 strains of Saccharomyces cerevisiae. We use conservation-based methods to predict the impact of protein-coding variation within genes on protein function. We then rank strains using a prediction score that measures the total sum of function-altering changes in different sets of genes reported to influence over 100 phenotypes in genome… CONTINUE READING
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