Predicting optimal dihydroartemisinin-piperaquine regimens to prevent malaria during pregnancy for HIV-infected women receiving efavirenz.

Abstract

Background A monthly treatment course of dihydroartemisinin-piperaquine (DHA-PQ) effectively prevents malaria during pregnancy. However, a drug-drug interaction pharmacokinetic (PK) study found that pregnant HIV-infected women receiving efavirenz-based antiretroviral therapy (ART) had markedly reduced piperaquine exposure. This suggests the need for… (More)
DOI: 10.1093/infdis/jix660

Cite this paper

@article{Wallender2017PredictingOD, title={Predicting optimal dihydroartemisinin-piperaquine regimens to prevent malaria during pregnancy for HIV-infected women receiving efavirenz.}, author={Erika K Wallender and Katarina M Vu{\vc}i{\'c}evi{\'c} and Prasanna Jagannathan and Liusheng Huang and Paul Natureeba and Abel Kakura and Mary K. Muhindo and Mirium Nakalembe and Diane V. Havlir and Moses Robert Kamya and Francesca T. Aweeka and Grant Dorsey and Philip J Rosenthal and Radojka M. Savic}, journal={The Journal of infectious diseases}, year={2017} }