Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering.

  title={Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering.},
  author={Fabien Dachet and Shruti Bagla and Gal Keren-Aviram and Andrew Morton and Karina Balan and Laleh Saadat and Tibor Valyi-Nagy and William Kupsky and Fei Song and Edward A. Dratz and Jeffrey A. Loeb},
  journal={Brain : a journal of neurology},
  volume={138 Pt 2},
  • F. Dachet, S. Bagla, J. Loeb
  • Published 1 February 2015
  • Biology, Psychology, Medicine
  • Brain : a journal of neurology
Although epilepsy is associated with a variety of abnormalities, exactly why some brain regions produce seizures and others do not is not known. We developed a method to identify cellular changes in human epileptic neocortex using transcriptional clustering. A paired analysis of high and low spiking tissues recorded in vivo from 15 patients predicted 11 cell-specific changes together with their 'cellular interactome'. These predictions were validated histologically revealing millimetre-sized… 

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