Predicting indirect readout effects in protein-DNA interactions.

@article{Zhang2004PredictingIR,
  title={Predicting indirect readout effects in protein-DNA interactions.},
  author={Y. Zhang and Z. Xi and R. Hegde and Z. Shakked and D. Crothers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 22},
  pages={
          8337-41
        }
}
  • Y. Zhang, Z. Xi, +2 authors D. Crothers
  • Published 2004
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • Recognition of DNA by proteins relies on direct interactions with specific DNA-functional groups, along with indirect effects that reflect variable energetics in the response of DNA sequences to twisting and bending distortions induced by proteins. Predicting indirect readout requires knowledge of the variations in DNA curvature and flexibility in the affected region, which we have determined for a series of DNA-binding sites for the E2 regulatory protein by using the cyclization kinetics… CONTINUE READING

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