Predicting genetic interactions from Boolean models of biological networks.

@article{Calzone2015PredictingGI,
  title={Predicting genetic interactions from Boolean models of biological networks.},
  author={Laurence Calzone and Emmanuel Barillot and Andrei Yu. Zinovyev},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2015},
  volume={7 8},
  pages={921-9}
}
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. Experimentally characterized genetic interaction networks in model organisms provide important insights into… CONTINUE READING