Predicting gefitinib responsiveness in lung cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens.

@article{Daniele2007PredictingGR,
  title={Predicting gefitinib responsiveness in lung cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens.},
  author={Lorenzo Daniele and Luigia Macr{\`i} and Marina Schena and Diego Dongiovanni and Lisa Bonello and Enrico Armando and Libero Ciuffreda and Oscar Bertetto and Gianni Bussolati and Anna Sapino},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 4},
  pages={1223-9}
}
In non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) mutational analysis is an excellent predictor of responsiveness to treatment with tyrosine kinase inhibitors, such as gefitinib. In up to 80% of NSCLCs, cytologic samples or endoscopic biopsies are the only specimens available for molecular analysis, but PCR amplification of DNA from small fixed and paraffin-embedded samples may create artifactual mutations. Fluorescence in situ hybridization (FISH) of EGFR and HER2… CONTINUE READING

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