Predicting expression patterns from regulatory sequence in Drosophila segmentation

  title={Predicting expression patterns from regulatory sequence in Drosophila segmentation},
  author={Eran Segal and Tali Raveh-Sadka and Mark D. Schroeder and Ulrich Unnerstall and Ulrike Gaul},
The establishment of complex expression patterns at precise times and locations is key to metazoan development, yet a mechanistic understanding of the underlying transcription control networks is still missing. Here we describe a novel thermodynamic model that computes expression patterns as a function of cis-regulatory sequence and of the binding-site preferences and expression of participating transcription factors. We apply this model to the segmentation gene network of Drosophila… CONTINUE READING
Highly Influential
This paper has highly influenced 28 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
255 Citations
55 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 255 extracted citations


Publications referenced by this paper.
Showing 1-10 of 55 references

The role of binding site cluster strength in Bicoiddependent patterning in Drosophila

  • A Ochoa-Espinosa
  • Proc. Natl Acad. Sci. USA 102,
  • 2005

Similar Papers

Loading similar papers…