Predicting enzyme class from protein structure without alignments.

@article{Dobson2005PredictingEC,
  title={Predicting enzyme class from protein structure without alignments.},
  author={Paul D. Dobson and Andrew J. Doig},
  journal={Journal of molecular biology},
  year={2005},
  volume={345 1},
  pages={187-99}
}
Methods for predicting protein function from structure are becoming more important as the rate at which structures are solved increases more rapidly than experimental knowledge. As a result, protein structures now frequently lack functional annotations. The majority of methods for predicting protein function are reliant upon identifying a similar protein and transferring its annotations to the query protein. This method fails when a similar protein cannot be identified, or when any similar… CONTINUE READING
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