Predicting effective microRNA target sites in mammalian mRNAs

  title={Predicting effective microRNA target sites in mammalian mRNAs},
  author={Vikram Agarwal and George W. Bell and Jin-Wu Nam and David P. Bartel and Elisa Izaurralde},
MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches suggest that many mRNAs are targeted through non-canonical interactions. Here, we show that recently reported non-canonical sites do not mediate repression despite binding the miRNA, which indicates that the vast majority of functional sites are… CONTINUE READING
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